反应条件
1: tert-butyl(5-ethyl-2-fluorophenoxy)dimethylsilane With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran; cyclohexane
T=-75°C; 2 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; cyclohexane
T=-75°C; 1 h;
3: With water; ammonium chloride in tetrahydrofuran; diethyl ether; cyclohexane
T=20°C;
参考文献
Eisai RandD Management Co., Ltd.
Patent: US2009/270433 A1, 2009 ;
Location in patent: Page/Page column 29 ;