5-甲基-1-苯基-1H-吡唑-4-甲酸乙酯合成路线 （共 18 条）
反应条件
in butan-1-ol 9 h; Heating;
参考文献
Bulletin de la Societe Chimique de France, , # 2 p. 318 - 324
反应条件
in diethyl ether 18 h; Ambient temperature; Yield given;
参考文献
Journal of Chemical Research, Miniprint, , # 5 p. 1401 - 1443
反应条件
Ohne Loesungsmittel;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 295, p. 320
反应条件
potassium hydroxide in ethanol 5 h; Heating;
参考文献
Menozzi; Mosti; Schenone
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 6 p. 1669 - 1675
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 20 °C / Cooling with ice 2: manganese(IV) oxide / tetrahydrofuran / 3 h / 70 °C View Scheme
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2308838 A1, 2011 ;
反应条件
1: 92 percent / KOH / ethanol / 5 h / Heating 2: 98 percent / 36 h / 200 °C View Scheme
参考文献
Menozzi; Mosti; Schenone
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 6 p. 1669 - 1675
反应条件
1: With diisobutylaluminium hydride in diethyl ether; hexane T=-75 - 70°C; 3.16667 h; 2: With hydrogenchloride in methanol; diethyl ether; hexane; water T=20°C; 0.333333 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/67462 A1, 2006 ;
Location in patent: Page/Page column 46-47 ;
WO 2006/067462 A1
反应条件
1: benzene / 6 h / Heating
2: aq. 30percent hydrogen peroxide, conc. sulfuric acid / CH2Cl2 / 4 h / Ambient temperature
3: 70percent aq. sulfuric acid / CH2Cl2 / 12 h
View Scheme
参考文献
Albrand, Michel; Gelin, Suzanne
Synthesis, 1983 , # 12 p. 1030 - 1031
