1: 1.) diisopropylamine, n-BuLi / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) THF, hexane, from -78 deg C to RT 2: thionyl chloride / benzene / 2.5 h / Heating 3: NH3 / dioxane / 2 h / Ambient temperature 4: P2O5 / toluene / 2 h / Heating 5: 1.) NaOCH3 / 1.) CH3OH, 2 h, 2.) CH3OH, 0 - 5 deg C, 0.25 h View Scheme

1: 1.) diisopropylamine, n-BuLi / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) THF, hexane, from -78 deg C to RT 2: thionyl chloride / benzene / 2.5 h / Heating 3: NH3 / dioxane / 2 h / Ambient temperature 4: P2O5 / toluene / 2 h / Heating 5: 1.) NaOCH3 / 1.) CH3OH, 2 h, 2.) CH3OH, 0 - 5 deg C, 0.25 h View Scheme

sodium methylate 1.) CH3OH, 2 h, 2.) CH3OH, 0 - 5 deg C, 0.25 h; Multistep reaction;