5-氟-1-苯并呋喃-2-羧酸合成路线 （共 4 条）
反应条件
sulfuric acid; potassium carbonate in butanone
参考文献
Reckitt and Colman Products Limited
Patent: US4411908 A1, 1983 ;
反应条件
1: 45 percent / sodium nitrite; HBF4; hydrochloric acid / H2O / 1 h / 0 °C
2: 87 percent / sodium hydroxide / dimethylformamide; methanol; H2O / 20 °C
View Scheme
参考文献
Wang, Yuqiang; Li, Lianfa; Ye, Wenqing; Tian, Zhiming; Jiang, Wei; Wang, Hong; Wright, Susan C.; Larrick, James W.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 4 p. 634 - 637
反应条件
1: K2CO3 / butan-2-one / 4 h / Heating
2: KOH / ethanol / 0.75 h / Heating
View Scheme
参考文献
Chapleo, Christopher B.; Myers, Peter L.; Butler, Richard C. M.; Davis, John A.; Doxey, John C.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 570 - 576
反应条件
trifluoroacetic acid in dichloromethane
T=0°C; 3 h; Inert atmosphere;
参考文献
Gensini, Martina; Altamura, Maria; Dimoulas, Tula; Fedi, Valentina; Giannotti, Danilo; Giuliani, Sandro; Guidi, Antonio; Harmat, Nicholas J. S.; Meini, Stefania; Nannicini, Rossano; Pasqui, Franco; Tramontana, Manuela; Triolo, Antonio; Maggi, Carlo Alberto
ChemMedChem, 2010 , vol. 5, # 1 p. 65 - 78
