5’-氯-5’-脱氧腺苷合成路线 （共 15 条）
反应条件
in N,N-dimethyl-formamide T=20°C;
参考文献
Ciuffreda, Pierangela; Loseto, Angela; Alessandrini, Laura; Terraneo, Giancarlo; Santaniello, Enzo
European Journal of Organic Chemistry, 2003 , # 24 p. 4748 - 4751
反应条件
in N,N-dimethyl-formamide T=20°C; 48 h;
参考文献
McCloskey, Diane E.; Bale, Shridhar; Secrist III, John A.; Tiwari, Anita; Moss III, Thomas H.; Valiyaveettil, Jacob; Brooks, Wesley H.; Guida, Wayne C.; Pegg, Anthony E.; Ealick, Steven E.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 5 p. 1388 - 1407
反应条件
2: acetate buffer / H2O / 40 °C / other oxyanion buffers; amine buffers View Scheme
参考文献
Vasquez, Peter J.; Coward, James K.
Journal of the Chemical Society, Chemical Communications, 1982 , # 12 p. 698 - 699
反应条件
1: NaH / dimethylformamide 2: 1.) pyridine, 2.) MCPBA / 2.) CH2Cl2, -40 deg C 3: 1.) diethylaminosulfur trifluoride, SbCl3, 2.) NH3 / 1.) CH2Cl2, room temp; 2.) MeOH View Scheme
参考文献
Robins; Wnuk
Tetrahedron Letters, 1988 , vol. 29, # 45 p. 5729 - 5732
反应条件
sodium azide in N,N-dimethyl-formamide
T=150°C; 1 h; Inert atmosphere;
参考文献
Shelton, Jadd R.; Burt, Scott R.; Peterson, Matt A.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1484 - 1487
