sodium hydroxide in ethanol 1.5 h; Heating; Yield given;

1: 83 percent / H2O; ethanol / 1.25 h / 100 °C 2: 96 percent / H2O / 2 h / 35 - 40 °C 3: 78 percent / 25percent NaOH / H2O / 2 h / Heating 4: 1.) 25percent aq. NaOH / 1.) DMF, room temp., 30 min; 2.) room temp., 3 h, 50 - 55 deg C, 30 min 5: 82 percent / sodium methoxide / methanol / 1.5 h / Heating 6: potassium carbonate / acetone / 24 h / Heating 7: 74 percent / potassium t-butoxide / tetrahydrofuran / 18 h 8: 80 percent / potassium carbonate / acetone / 48 h / Heating 9: 10percent aqueous NaOH / aq. ethanol / 1.5 h / Heating View Scheme

1: 96 percent / H2O / 2 h / 35 - 40 °C 2: 78 percent / 25percent NaOH / H2O / 2 h / Heating 3: 1.) 25percent aq. NaOH / 1.) DMF, room temp., 30 min; 2.) room temp., 3 h, 50 - 55 deg C, 30 min 4: 82 percent / sodium methoxide / methanol / 1.5 h / Heating 5: potassium carbonate / acetone / 24 h / Heating 6: 74 percent / potassium t-butoxide / tetrahydrofuran / 18 h 7: 80 percent / potassium carbonate / acetone / 48 h / Heating 8: 10percent aqueous NaOH / aq. ethanol / 1.5 h / Heating View Scheme

1: potassium carbonate / acetone / 24 h / Heating 2: 74 percent / potassium t-butoxide / tetrahydrofuran / 18 h 3: 80 percent / potassium carbonate / acetone / 48 h / Heating 4: 10percent aqueous NaOH / aq. ethanol / 1.5 h / Heating View Scheme

1: 1.) 25percent aq. NaOH / 1.) DMF, room temp., 30 min; 2.) room temp., 3 h, 50 - 55 deg C, 30 min 2: 82 percent / sodium methoxide / methanol / 1.5 h / Heating 3: potassium carbonate / acetone / 24 h / Heating 4: 74 percent / potassium t-butoxide / tetrahydrofuran / 18 h 5: 80 percent / potassium carbonate / acetone / 48 h / Heating 6: 10percent aqueous NaOH / aq. ethanol / 1.5 h / Heating View Scheme

1: 78 percent / 25percent NaOH / H2O / 2 h / Heating 2: 1.) 25percent aq. NaOH / 1.) DMF, room temp., 30 min; 2.) room temp., 3 h, 50 - 55 deg C, 30 min 3: 82 percent / sodium methoxide / methanol / 1.5 h / Heating 4: potassium carbonate / acetone / 24 h / Heating 5: 74 percent / potassium t-butoxide / tetrahydrofuran / 18 h 6: 80 percent / potassium carbonate / acetone / 48 h / Heating 7: 10percent aqueous NaOH / aq. ethanol / 1.5 h / Heating View Scheme

1: 80 percent / potassium carbonate / acetone / 48 h / Heating 2: 10percent aqueous NaOH / aq. ethanol / 1.5 h / Heating View Scheme

1: 74 percent / potassium t-butoxide / tetrahydrofuran / 18 h 2: 80 percent / potassium carbonate / acetone / 48 h / Heating 3: 10percent aqueous NaOH / aq. ethanol / 1.5 h / Heating View Scheme

1: 82 percent / sodium methoxide / methanol / 1.5 h / Heating 2: potassium carbonate / acetone / 24 h / Heating 3: 74 percent / potassium t-butoxide / tetrahydrofuran / 18 h 4: 80 percent / potassium carbonate / acetone / 48 h / Heating 5: 10percent aqueous NaOH / aq. ethanol / 1.5 h / Heating View Scheme