acetic acid in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water

in water T=35 - 40°C; 2 h;

1: 83 percent / H2O; ethanol / 1.25 h / 100 °C 2: 96 percent / H2O / 2 h / 35 - 40 °C View Scheme

1: 78 percent / 25percent NaOH / H2O / 2 h / Heating 2: 1.) 25percent aq. NaOH / 1.) DMF, room temp., 30 min; 2.) room temp., 3 h, 50 - 55 deg C, 30 min 3: 82 percent / sodium methoxide / methanol / 1.5 h / Heating 4: potassium carbonate / acetone / 24 h / Heating 5: 74 percent / potassium t-butoxide / tetrahydrofuran / 18 h 6: 80 percent / potassium carbonate / acetone / 48 h / Heating 7: 10percent aqueous NaOH / aq. ethanol / 1.5 h / Heating View Scheme

1: 78 percent / 25percent NaOH / H2O / 2 h / Heating 2: 1.) 25percent aq. NaOH / 1.) DMF, room temp., 30 min; 2.) room temp., 3 h, 50 - 55 deg C, 30 min 3: 82 percent / sodium methoxide / methanol / 1.5 h / Heating 4: potassium carbonate / acetone / 24 h / Heating 5: 74 percent / potassium t-butoxide / tetrahydrofuran / 18 h 6: 80 percent / potassium carbonate / acetone / 48 h / Heating 7: 72 percent / anhydrous ammonia, lithium / hydrated ferric nitrate / tetrahydrofuran / 16 h View Scheme

sodium hydroxide in water 2 h; Heating;