2-氨基-2-硫代乙基氨基甲酸叔丁酯合成路线 （共 11 条）
反应条件
Lawesson's reagent in tetrahydrofuran T=20°C; 16 h;
参考文献
SCHERING CORPORATION
Patent: WO2005/121130 A2, 2005 ;
Location in patent: Page/Page column 391-392 ;
WO 2005/121130 A2
反应条件
hydrogen sulfide; diethylamine in toluene T=-10 - 20°C;
参考文献
Abbott GmbH and Co., KG
Patent: US6740647 B1, 2004 ;
Location in patent: Page column 37 ;
US 6740647 B1
反应条件
Lawesson's reagent in dichloromethane T=25°C; 16 h;
参考文献
Flentge, Charles A.; Chen, Hui-Ju; DeGoey, David A.; Flosi, William J.; Grampovnik, David J.; Huang, Peggy P.; Kempf, Dale J.; Klein, Larry L.; Krueger, Allan C.; Madigan, Darold L.; Randolph, John T.; Sun, Minghua; Yeung, Ming C.; Zhao, Chen
Patent: US2005/131042 A1, 2005 ;
Location in patent: Page/Page column 123 ;
反应条件
1: 89 percent / aq. Et3N / tetrahydrofuran / Ambient temperature 2: 89 percent / Lawesson's reagent / 1,2-dimethoxy-ethane / Ambient temperature View Scheme
参考文献
Angewandte Chemie, , vol. 108, # 13/14 p. 1604 - 1607
反应条件
1: aq. MH3 / tetrahydrofuran / 0.75 h / -10 °C 2: 85 percent / Lawesson's reagent / CH2Cl2 / 16 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 3 p. 601 - 607
反应条件
1: CaCO3 / ethanol / 20 °C 2: isobutyl chloroformate; aq. NH3; NMM / tetrahydrofuran 3: (CF3CO)2O; Et3N / CH2Cl2 View Scheme
参考文献
Bhansali, Pravin; Hanigan, Christin L.; Casero, Robert A.; Tillekeratne, L. M. Viranga
Journal of Medicinal Chemistry, 2011 , vol. 54, # 21 p. 7453 - 7463
反应条件
in diethyl ether 2 h; Ambient temperature;
参考文献
Bailly, Christian; Houssin, Raymond; Bernier, Jean-Luc; Henichart, Jean-Pierre
Tetrahedron, 1988 , vol. 44, # 18 p. 5833 - 5844
反应条件
1: KHCO3 / 1,2-dimethoxy-ethane / 16 h / -15 °C 2: TFAA, 2,6-lutidine / 1,2-dimethoxy-ethane / 0.5 h / -10 °C View Scheme
参考文献
Moody, Christopher J.; Bagley, Mark C.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 3 p. 601 - 607
反应条件
calcium carbonate in ethanol
Inert atmosphere;
参考文献
Souto, Jose A.; Vaz, Esther; Lepore, Ilaria; Poeppler, Ann-Christin; Franci, Gianluigi; Alvarez, Rosana; Altucci, Lucia; De Lera, Angel R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 12 p. 4654 - 4667
反应条件
1: KHCO3 / 1,2-dimethoxy-ethane / 16 h / -15 °C
2: TFAA, 2,6-lutidine / 1,2-dimethoxy-ethane / 0.5 h / -10 °C
3: 87 percent / aq. LiOH / methanol / 3 h / Ambient temperature
View Scheme
参考文献
Bernier; Houssin; Henichart
Tetrahedron, 1986 , vol. 42, # 10 p. 2695 - 2702
