2-(4-二苯甲基哌嗪)乙基 乙酰乙酸酯合成路线 （共 10 条）
反应条件
1: 28percent NH4OH, / methanol; H2O / 16 h / Heating 2: methanol / 4.5 h / Heating 3: 94 percent / Et3N, / methanol / 16 h / Heating 4: 52 percent / POCl3, / 3 h / Heating View Scheme
参考文献
Cho; Ueda; Mizuno; Ishihara; Aisaka; Noguchi
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 8 p. 2117 - 2121
反应条件
in isopropyl alcohol 6 h; Heating;
参考文献
Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797
反应条件
1: piperidine / benzene / 5 h / Heating 2: propan-2-ol / 7 h / Heating View Scheme
参考文献
Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797
反应条件
1: 20 percent NH3/EtOH 2: 17.8 percent / propan-2-ol / 6 h / Heating View Scheme
参考文献
Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797
反应条件
1: 20 percent NH3/EtOH 2: 17.8 percent / propan-2-ol / 6 h / Heating 3: 90.1 percent / 2 N HNO3 / dioxane / 1.5 h / 70 °C View Scheme
参考文献
Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797
反应条件
1: 20 percent NH3/EtOH 2: 17.8 percent / propan-2-ol / 6 h / Heating View Scheme
参考文献
Meguro; Aizawa; Sohda; Kawamatsu; Nagaoka
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3787 - 3797
反应条件
triethylamine in chloroform
10 h; Ambient temperature;
参考文献
Kobayashi; Inoue; Nishino; Fujihara; Oizumi; Kimura
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 5 p. 797 - 817
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4603135 A1, 1986 ;
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4892875 A1, 1990 ;
反应条件
1: 66 percent / K2CO3 / dimethylformamide / 60 °C
2: 59.1 percent / Et3N / CHCl3 / 10 h / Ambient temperature
View Scheme
参考文献
Kobayashi; Inoue; Nishino; Fujihara; Oizumi; Kimura
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 5 p. 797 - 817
