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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
892414-46-9
合成路线
（共 8 条）
892414-45-8
→
反应条件
892414-46-9
反应条件
hydrogen; nickel in ethanol T=20°C;
参考文献
Schirok, Hartmut; Figueroa-Perez, Santiago; Thutewohl, Michael; Paulsen, Holger; Kroh, Walter; Klewer, Dagmar
Synthesis, 2007 , # 2 p. 251 - 258
372-48-5
2-氟吡啶
→
反应条件
892414-46-9
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / 1.5 h / -75 °C 1.2: tetrahydrofuran 2.1: 290 g / potassium carbonate / tetrahydrofuran / 20 °C 3.1: 81 percent / H2 / Raney-nickel / ethanol / 20 °C View Scheme
参考文献
Schirok, Hartmut; Figueroa-Perez, Santiago; Thutewohl, Michael; Paulsen, Holger; Kroh, Walter; Klewer, Dagmar
Synthesis, 2007 , # 2 p. 251 - 258
932406-33-2
→
反应条件
892414-46-9
反应条件
1: 290 g / potassium carbonate / tetrahydrofuran / 20 °C 2: 81 percent / H2 / Raney-nickel / ethanol / 20 °C View Scheme
参考文献
Schirok, Hartmut; Figueroa-Perez, Santiago; Thutewohl, Michael; Paulsen, Holger; Kroh, Walter; Klewer, Dagmar
Synthesis, 2007 , # 2 p. 251 - 258
892414-46-9
→
反应条件
892414-47-0
3-(三氟甲基)-1H-吡咯并[2,3-b]吡啶
反应条件
1: With pyridine; thionyl chloride in tetrahydrofuran T=0 - 20°C; 24 h; 2: With sodium carbonate in tetrahydrofuran; water pH=6; Cooling with ice water;
参考文献
AC Immune, S.A.
Patent: US2011/280808 A1, 2011 ;
Location in patent: Page/Page column 80 ;
892414-46-9
→
反应条件
892414-48-1
反应条件
1: 83 percent / thionyl chloride; pyridine / CH2Cl2 / 20 °C 2: 79 percent / m-chloroperbenzoic acid / ethyl acetate / 1 h / 0 °C View Scheme
参考文献
AC Immune, S.A.
Patent: US2011/280808 A1, 2011 ;
892414-46-9
→
反应条件
892414-49-2
反应条件
1: 83 percent / thionyl chloride; pyridine / CH2Cl2 / 20 °C 2: 79 percent / m-chloroperbenzoic acid / ethyl acetate / 1 h / 0 °C 3: 76 percent / aq. nitric acid / trifluoroacetic acid / 2 h / 70 °C View Scheme
参考文献
Schirok, Hartmut; Figueroa-Perez, Santiago; Thutewohl, Michael; Paulsen, Holger; Kroh, Walter; Klewer, Dagmar
Synthesis, 2007 , # 2 p. 251 - 258
892414-46-9
→
反应条件
892414-50-5
6-氯-4-硝基-3-(三氟甲基)-1H-吡咯并[2,3-B]吡啶
反应条件
1: 83 percent / thionyl chloride; pyridine / CH2Cl2 / 20 °C 2: 79 percent / m-chloroperbenzoic acid / ethyl acetate / 1 h / 0 °C 3: 76 percent / aq. nitric acid / trifluoroacetic acid / 2 h / 70 °C 4: 100 percent / hexamethyldisilazane; trichloroacetyl chloride / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Schirok, Hartmut; Figueroa-Perez, Santiago; Thutewohl, Michael; Paulsen, Holger; Kroh, Walter; Klewer, Dagmar
Synthesis, 2007 , # 2 p. 251 - 258
892414-46-9
→
反应条件
892414-51-6
反应条件
1: 83 percent / thionyl chloride; pyridine / CH2Cl2 / 20 °C 2: 79 percent / m-chloroperbenzoic acid / ethyl acetate / 1 h / 0 °C 3: 76 percent / aq. nitric acid / trifluoroacetic acid / 2 h / 70 °C 4: 100 percent / hexamethyldisilazane; trichloroacetyl chloride / tetrahydrofuran / 0 - 20 °C 5: 65 percent / sodium hydride / dimethylformamide; various solvent(s) / 0.75 h / 20 °C View Scheme
参考文献
Schirok, Hartmut; Figueroa-Perez, Santiago; Thutewohl, Michael; Paulsen, Holger; Kroh, Walter; Klewer, Dagmar
Synthesis, 2007 , # 2 p. 251 - 258
