4-溴-(9ci)-1H-吲哚-3-乙酸合成路线 （共 13 条）
反应条件
1: 88.5 percent / 40percent aq. NaOH / methanol / 1 h / Heating 2: 96.3 percent / H2O; acetic acid / 48 h / Ambient temperature 3: 89.1 percent / dimethylformamide; H2O / 1 h / Heating 4: 77.7 percent / 40percent aq. NaOH / methanol / 2 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 9 p. 3696 - 3708
反应条件
1: 60.5 percent / 40percent NaOH / methanol / 1.5 h / Heating 2: 96.3 percent / H2O; acetic acid / 48 h / Ambient temperature 3: 89.1 percent / dimethylformamide; H2O / 1 h / Heating 4: 77.7 percent / 40percent aq. NaOH / methanol / 2 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 9 p. 3696 - 3708
反应条件
1: methanol With thionyl chloride
T=-15 - -10°C; 0.5 h;
2: 4-bromo-3-indoleacetic acid T=20°C; 2 h;
参考文献
ONO PHARMACEUTICAL CO., LTD.
Patent: WO2006/90817 A1, 2006 ;
Location in patent: Page/Page column 147-148 ;
