1: With sodium hydroxide; urea hydrogen peroxide addition compound in water
T=50°C;
2: With hydrogenchloride in water
T=25°C; pH=1; 0.5 h;
3: With sodium hydroxide in water
T=50 - 60°C; pH=5 - 5.5; 0.5 h;
参考文献
Anadys Pharmaceuticals, Inc.
Patent: US2007/117979 A1, 2007 ;
Location in patent: Page/Page column 4 ;