(2-溴吡啶-4-基)(吡咯烷-1-基)甲酮合成路线 (共 1 条)
反应条件
1: 2-bromo-4-pyridinecarboxylic acid With oxalyl dichloride in dichloromethane
T=0 - 20°C; 2 h;
2: pyrrolidine With triethylamine; 4-(N,N-dimethlyamino)pyridine in dichloromethane
T=0 - 20°C; 1 h;
参考文献
ASTRAZENECA AB
Patent: WO2006/65209 A1, 2006 ;
Location in patent: Page/Page column 23 ;
WO 2006/065209 A1