反应条件
1: 4-chloro-1-{[(4-chloro-2-fluorophenyl)methyl]oxy}-2-iodobenzene With isopropylmagnesium chloride in tetrahydrofuran; toluene
T=-12 - -5°C; Large scale reaction;
2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; toluene
T=10 - 22°C; Large scale reaction;
参考文献
Whiting, Matthew; Harwood, Kathy; Hossner, Frank; Turner, Peter G.; Wilkinson, Mark C.
Organic Process Research and Development, 2010 , vol. 14, # 4 p. 820 - 831