1: 85 percent / LDA / tetrahydrofuran / 48 h / 25 °C 2: 89 percent / MCPBA / CH2Cl2 / 1 h / -35 - 0 °C 3: tetrabutylammonium fluoride, 4A molecular sieves / tetrahydrofuran / Ambient temperature; 1.) overnight, 2.) 2 h View Scheme

1: 89 percent / MCPBA / CH2Cl2 / 1 h / -35 - 0 °C 2: tetrabutylammonium fluoride, 4A molecular sieves / tetrahydrofuran / Ambient temperature; 1.) overnight, 2.) 2 h View Scheme

4 A molecular sieve; tetrabutyl ammonium fluoride in tetrahydrofuran Ambient temperature1.) overnight, 2.) 2 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

sodium hydroxide; n-butyllithium 1.) THF, hexane, -60 deg C, 10 min, 2.) THF, 3 h, -60 deg C; Yield given. Multistep reaction;

T=-60°C; 3 h; Product distribution;