2,4-二羟基-3-硝基吡啶合成路线 （共 28 条）
反应条件
1: 80 percent / POCl3 / 24 h / Heating 2: 90 percent / SnCl2*2H2O; conc. aq. HCl / diethyl ether / 20 °C View Scheme
参考文献
den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 673,690
反应条件
1: acetic acid; bromine / 70 °C
2: phosphoryl chloride / 120 °C
3: iron-powder; acetic acid
4: sodium nitrite; copper-powder; aqueous hydrochloric acid / Diazotization
View Scheme
参考文献
Kolder; den Hertog
Recueil des Travaux Chimiques des Pays-Bas, 1953 , vol. 72, p. 853,858
反应条件
1: 77 percent / POCl3 / 90 - 100 °C
2: 33 g / triethylamine / dimethylformamide / 2 h / 20 °C
View Scheme
参考文献
Crey-Desbiolles, Caroline; Kotera, Mitsuharu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1935 - 1941
反应条件
1: 77 percent / POCl3 / 90 - 100 °C
2: 33 g / triethylamine / dimethylformamide / 2 h / 20 °C
3: 28.6 g / H2; Raney Ni / methanol / 3.5 h / 20 °C
View Scheme
参考文献
Crey-Desbiolles, Caroline; Kotera, Mitsuharu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1935 - 1941
反应条件
1: 77 percent / POCl3 / 90 - 100 °C
2: 33 g / triethylamine / dimethylformamide / 2 h / 20 °C
3: 28.6 g / H2; Raney Ni / methanol / 3.5 h / 20 °C
4: 20.1 g / acetic anhydride / 1.5 h / Heating
View Scheme
参考文献
Crey-Desbiolles, Caroline; Kotera, Mitsuharu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1935 - 1941
反应条件
1: phosphoryl chloride
2: iron-powder; acetic acid
3: HCl; acetic acid; aqueous H2O2
View Scheme
参考文献
den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 673,690
反应条件
1: 2,4-Dihydroxy-3-nitropyridine With sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.25 h;
2: benzyl bromide in N,N-dimethyl-formamide
T=0 - 55°C; 17 h;
3: With hydrogenchloride in water; N,N-dimethyl-formamide
参考文献
Takeda Pharmaceutical Company Limited; Array BioPharma Inc.
Patent: US7169926 B1, 2007 ;
Location in patent: Page/Page column 73-74 ;
US 7169926 B1
反应条件
1: 2,4-Dihydroxy-3-nitropyridine With sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.25 h;
2: ethyl iodide in N,N-dimethyl-formamide
T=0 - 55°C; 17 h;
参考文献
Takeda Pharmaceutical Company Limited; Array BioPharma Inc.
Patent: US7169926 B1, 2007 ;
Location in patent: Page/Page column 77 ;
US 7169926 B1
