2-甲基-[1,1-联苯]-4-羧酸甲酯合成路线 （共 5 条）
反应条件
1: With methanol; sodium hydroxide; water 2 h; Heating / reflux; 2: With hydrogenchloride in water
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/66173 A2, 2006 ;
Location in patent: Page/Page column 106 ;
WO 2006/066173 A2
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in toluene
T=90°C; 18 h;
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HAN, Xiaochun; LOU, Yan; MICHOUD, Christophe; MISCHKE, Steven Gregory; REMISZEWSKI, Stacy; RUPERT, Kenneth Carey
Patent: WO2014/9495 A1, 2014 ;
Location in patent: Page/Page column 49 ;
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in propan-1-ol; water
Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/66173 A2, 2006 ;
Location in patent: Page/Page column 105-106 ;
WO 2006/066173 A2
反应条件
1: 95 percent / potassium carbonate / acetone / 10 h / Heating
2: 92 percent / H2 / Pd/C / 72 h / 2280 Torr / Ambient temperature
View Scheme
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Perozzo, Valentina; Serra, Stefano
Tetrahedron, 1997 , vol. 53, # 44 p. 15029 - 15040
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether; water
Reflux;
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420
