齐墩果-12-烯[2,3-c][1,2,5]恶二唑-28-酸苯甲酯合成路线 （共 7 条）
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran T=20°C;
参考文献
Chen, Jun; Liu, Jun; Zhang, Luyong; Wu, Guanzhong; Hua, Weiyi; Wu, Xiaoming; Sun, Hongbin
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 11 p. 2915 - 2919
反应条件
1: 58 percent / NaNO2; aq. H2SO4 / methanol; tetrahydrofuran / 20 °C
2: 80 percent / hydroxylamine hydrochloride; pyridine / 80 °C
3: 82 percent / NaOH / ethane-1,2-diol / 0.5 h / 200 °C
View Scheme
参考文献
Chen, Jun; Liu, Jun; Zhang, Luyong; Wu, Guanzhong; Hua, Weiyi; Wu, Xiaoming; Sun, Hongbin
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 11 p. 2915 - 2919
反应条件
1: 80 percent / hydroxylamine hydrochloride; pyridine / 80 °C
2: 82 percent / NaOH / ethane-1,2-diol / 0.5 h / 200 °C
View Scheme
参考文献
Chen, Jun; Liu, Jun; Zhang, Luyong; Wu, Guanzhong; Hua, Weiyi; Wu, Xiaoming; Sun, Hongbin
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 11 p. 2915 - 2919
反应条件
1: 89 percent / PCC / CH2Cl2 / 20 °C
2: 58 percent / NaNO2; aq. H2SO4 / methanol; tetrahydrofuran / 20 °C
3: 80 percent / hydroxylamine hydrochloride; pyridine / 80 °C
4: 82 percent / NaOH / ethane-1,2-diol / 0.5 h / 200 °C
View Scheme
参考文献
Chen, Jun; Liu, Jun; Zhang, Luyong; Wu, Guanzhong; Hua, Weiyi; Wu, Xiaoming; Sun, Hongbin
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 11 p. 2915 - 2919
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 60 °C
2: 89 percent / PCC / CH2Cl2 / 20 °C
3: 58 percent / NaNO2; aq. H2SO4 / methanol; tetrahydrofuran / 20 °C
4: 80 percent / hydroxylamine hydrochloride; pyridine / 80 °C
5: 82 percent / NaOH / ethane-1,2-diol / 0.5 h / 200 °C
View Scheme
参考文献
Chen, Jun; Liu, Jun; Zhang, Luyong; Wu, Guanzhong; Hua, Weiyi; Wu, Xiaoming; Sun, Hongbin
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 11 p. 2915 - 2919
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 60 °C
2: 89 percent / PCC / CH2Cl2 / 20 °C
3: 58 percent / NaNO2; aq. H2SO4 / methanol; tetrahydrofuran / 20 °C
4: 80 percent / hydroxylamine hydrochloride; pyridine / 80 °C
5: 82 percent / NaOH / ethane-1,2-diol / 0.5 h / 200 °C
View Scheme
参考文献
Chen, Jun; Liu, Jun; Zhang, Luyong; Wu, Guanzhong; Hua, Weiyi; Wu, Xiaoming; Sun, Hongbin
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 11 p. 2915 - 2919
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C
2.1: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / 12 h / 20 °C
3.1: potassium tert-butylate / tert-butyl alcohol / 1 h / 20 °C
3.2: 5 h / 20 °C
4.1: hydroxylamine hydrochloride / pyridine / 4 h / Reflux
5.1: potassium hydroxide / 1,4-dioxane; ethylene glycol / 5 h / Reflux
View Scheme
参考文献
Li, Hui; Zou, Hui; Gao, Lixin; Liu, Ting; Yang, Fan; Li, Jingya; Li, Jia; Qiu, Wen-Wei; Tang, Jie
Heterocycles, 2012 , vol. 85, # 5 p. 1117 - 1139
