(S)-3-(4-硝基苯基)2-氨基-1-丙醇合成路线 （共 5 条）
反应条件
potassium hydroxide in toluene T=0 - 20°C; 2 h;
参考文献
Moloney, Gerard P.; Robertson, Alan D.; Martin, Graeme R.; MacLennan, Steven; Mathews, Neil; Dodsworth, Susan; Sang, Pang Yih; Knight, Cameron; Glen, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 15 p. 2347 - 2362
反应条件
1: With potassium carbonate in toluene T=10 - 15°C; 2: With water in toluene T=20 - 25°C; Product distribution / selectivity;
参考文献
MATRIX LABORATORIES LTD
Patent: WO2008/18090 A2, 2008 ;
Location in patent: Page/Page column 9 ;
反应条件
1: 36 percent / aq. KOH / toluene / 1 h / 0 °C 2: 97 percent / H2, aq. 2 N HCl / 10percent Pd/C / ethanol; ethyl acetate 3: 1.) aq. HCl, NaNO2, 2.) SnCl2 / 1.) from -5 deg C to 0 deg C, 30 min, 2.) RT, 3 h 4: 0.21 g / ethanol; H2O / 2 h / Heating View Scheme
参考文献
Glen, Robert C.; Martin, Graeme R.; Hill, Alan P.; Hyde, Richard M.; Woollard, Patrick M.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3566 - 3580
反应条件
1: 75 percent / 0.2M aq. KOH / toluene / 2 h / 0 - 20 °C 2: 79 percent / H2, aq. HCl / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Moloney, Gerard P.; Robertson, Alan D.; Martin, Graeme R.; MacLennan, Steven; Mathews, Neil; Dodsworth, Susan; Sang, Pang Yih; Knight, Cameron; Glen, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 15 p. 2347 - 2362
反应条件
1: 75 percent / 0.2M aq. KOH / toluene / 2 h / 0 - 20 °C
2: 79 percent / H2, aq. HCl / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
3: conc. aq. HCl, NaNO2 / 0.5 h / 0 °C
4: 1.) aq. KOH, 3.) aq. HCl
5: polyphosphoric ester / CHCl3 / 8 h / Heating
View Scheme
参考文献
Moloney, Gerard P.; Robertson, Alan D.; Martin, Graeme R.; MacLennan, Steven; Mathews, Neil; Dodsworth, Susan; Sang, Pang Yih; Knight, Cameron; Glen, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 15 p. 2347 - 2362
