1: piperazine With hydrogenchloride in ethanol T=70°C; 2 h; 2: 4-bromomethyl-benzonitrile in ethanol 16 h; Heating / reflux; 3: With potassium hydroxide in dichloromethane; water
参考文献
Teijin Intellectual Property Center Limited; Combichem, Inc.
Patent: US6686353 B1, 2004 ;
Location in patent: Page/Page column 109-110 ;
US 6686353 B1