1: 2-(4-bromo-thiophen-2-yl)-[1,3]dioxolane With n-butyllithium in diethyl ether; hexane
T=-78°C; 0.416667 h;
2: carbon dioxide With hydrogenchloride; water in diethyl ether; hexane
0.5 h; Cooling with dry ice;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/76440 A1, 2003 ;
Location in patent: Page/Page column 58 ;
WO 03/076440 A1