MgI2 etherate in acetonitrile T=80°C; Clauson-Kaas pyrrole synthesis; 10 h; chemoselective reaction;

1-hydroxy-pyrrolidine-2,5-dione; copper(l) iodide; sodium methylate in dimethyl sulfoxide T=90°C; 12 h;

hydrogen; palladium on activated charcoal

1: 75.4 percent / acetic acid 2: 47.6 percent / hydrogen / 10percent Pd/C View Scheme

acetic acid 1 h; Reflux;

1: 89 percent / 0.5 h / 120 °C 2: 65 percent / diphenyl ether / 30 h / Heating 3: 85.4 percent / 10percent sodium hydroxide / H2O / 1 h / Heating 4: 65.1 percent / dimethylformamide / 4 h / 80 °C 5: 30 percent / hydrogen / 5percent Rh/Al2O3 / acetic acid / 7 h / 50 °C / 3040 Torr 6: 70 percent / 10percent sodium hydroxide / H2O / 1 h / Heating View Scheme

1: 89 percent / 0.5 h / 120 °C 2: 65 percent / diphenyl ether / 30 h / Heating 3: 85.4 percent / 10percent sodium hydroxide / H2O / 1 h / Heating View Scheme