6-溴-3,4-二氢异喹啉-2(1H)-甲酸叔丁酯合成路线 （共 8 条）
反应条件
triethylamine in methanol T=20°C; 20 h; Inert atmosphere;
参考文献
WO2010/145202 A1, ;
Page/Page column 35-36 ;
WO 2010/145202 A1
反应条件
triethylamine in dichloromethane T=0 - 35°C; 16 h;
参考文献
WO2013/80222 A1, ;
Page/Page column 40 ;
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile T=60 - 80°C; 2 h;
参考文献
WO2009/1128 A1, ;
Page/Page column 51 ;
WO 2009/001128 A1
反应条件
1: With N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=20°C; 2: With phosphoric acid; water in tetrahydrofuran pH=2;
参考文献
US2008/171754 A1, ;
Page/Page column 101; 102 ;
US 20080171754 A1
反应条件
1: acetic acid; sodium tetrahydroborate / 2 h / 20 - 35 °C 2: triethylamine / dichloromethane / 16 h / 0 - 35 °C View Scheme
反应条件
potassium acetate; 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane T=90°C; 4 h; Inert atmosphere;
参考文献
WO2010/145202 A1, ;
Page/Page column 36-37 ;
WO 2010/145202 A1
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in N,N-dimethyl-formamide T=85°C; 4 h;
参考文献
US2008/171754 A1, ;
Page/Page column 102 ;
US 20080171754 A1
反应条件
N,N-dimethylethylenediamine; sodium iodide; copper(l) iodide in 1,4-dioxane T=20 - 110°C; 14 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: WO2009/103478 A1, 2009 ;
Location in patent: Page/Page column 64 ;
WO 2009/103478 A1
