6-溴-5-氟-1,3-二氢-吲哚-2-酮合成路线 （共 2 条）
反应条件
1: With lithium chloride in water; dimethyl sulfoxide
T=100°C; 3 h;
2: With iron; acetic acid
T=100°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; TREU, Matthias; KARNER, Thomas; REISER, Ulrich
Patent: WO2010/12747 A1, 2010 ;
Location in patent: Page/Page column 14-15 ;
反应条件
1: With sodium hydride in 1,4-dioxane; mineral oil
T=11 - 20°C; 17.75 h;
2: With hydrogenchloride; water
7 h; Reflux;
3: With iron; acetic acid
T=100°C; 7 h;
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BRUNNER, Daniela; MALBERG, Jessica; SHANKAR, Bavani G.; KOLCZEWSKI, Sabine; LIMBERG, Anja; PRINSSEN, Eric; RIEMER, Claus; STOLL, Theodor
Patent: WO2014/40969 A1, 2014 ;
Location in patent: Page/Page column 29-30 ;
