反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C 2: Chiralpak AD / methanol; ethanol; n-heptane / |Resolution of racemate 3: palladium on activated charcoal; hydrogen / ethanol / 18 h / 20 °C View Scheme
参考文献
NOVARTIS AG; CARAVATTI, Giorgio; CHAMOIN, Sylvie; FURET, Pascal; HOGENAUER, Klemens; HURTH, Konstanze; KALIS, Christoph; KAMMERTOENS, Karen; LEWIS, Ian; MOEBITZ, Henrik; SMITH, Alexander Baxter; SOLDERMANN, Nicolas; WOLF, Romain; ZECRI, Frederic
Patent: US2013/165436 A1, 2013 ;