4-溴-2-甲氧基苯乙酮合成路线 （共 12 条）
参考文献
US5332757 A1, ;
US 5332757 A
参考文献
US5332757 A1, ;
US 5332757 A
反应条件
sodium hypobromide in 1,4-dioxane; water 1.) ice-bath, 20 min, 2.) room temperature, 30 min, 3.) reflux, 2.5 h;
参考文献
Novak, Jiri; Salemink, Cornelis A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2867 - 2871
反应条件
potassium carbonate in N,N-dimethyl-formamide
20 h; Ambient temperature;
参考文献
Novak, Jiri; Salemink, Cornelis A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2867 - 2871
反应条件
1: 3-methoxybromobenzene With triethylsilane; AlCl3, aluminium chloride in dichloromethane
T=0°C; Friedel-Craft's Reaction; 1.16667 h; Inert atmosphere;
2: acetyl chloride in dichloromethane
2 h;
参考文献
GENFIT
Patent: US2010/4159 A1, 2010 ;
Location in patent: Page/Page column 59-60 ;
反应条件
1: 1-(4-bromo-2-hydroxyphenyl)ethan-1-one With potassium carbonate in acetone
T=50°C; 0.5 h; Inert atmosphere;
2: dimethyl sulfate in acetone
T=50°C; Inert atmosphere;
参考文献
Wang, Chen; Dong, Jinyun; Zhang, Yanmin; Wang, Fang; Gao, Hongping; Li, Pengfei; Wang, Sicen; Zhang, Jie
MedChemComm, 2013 , vol. 4, # 11 p. 1434 - 1438
反应条件
hydrogenchloride; N-bromosuccinmide in acetone
T=20°C; Bromination; 0.733333 h;
参考文献
Andersh, Brad; Murphy, Drew L.; Olson, Ryan J.
Synthetic Communications, 2000 , vol. 30, # 12 p. 2091 - 2098
反应条件
1.1: AlCl3, aluminium chloride / 2 h / 160 °C / |Inert atmosphere
2.1: potassium carbonate / acetone / 0.5 h / 50 °C / |Inert atmosphere
2.2: 50 °C / |Inert atmosphere
View Scheme
参考文献
Wang, Chen; Dong, Jinyun; Zhang, Yanmin; Wang, Fang; Gao, Hongping; Li, Pengfei; Wang, Sicen; Zhang, Jie
MedChemComm, 2013 , vol. 4, # 11 p. 1434 - 1438
反应条件
lithium perchlorate
T=100°C; 5 h;
参考文献
Bartoli, Giuseppe; Bosco, Marcella; Marcantoni, Enrico; Massaccesi, Massimo; Rinaldi, Samuele; Sambri, Letizia
Tetrahedron Letters, 2002 , vol. 43, # 36 p. 6331 - 6333
反应条件
1.1: pyridine / 2.5 h / |Cooling with ice
2.1: AlCl3, aluminium chloride / 2 h / 160 °C
3.1: potassium carbonate / acetone / 0.5 h / 50 °C
3.2: 50 °C
View Scheme
参考文献
Wang, Chen; Gao, Hongping; Dong, Jinyun; Zhang, Yanmin; Su, Ping; Shi, Yaling; Zhang, Jie
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 277 - 284
