1: 4.6 g / NEt3 / dimethylformamide / Ambient temperature 2: 0.4 g / conc. aq. HCl / acetonitrile / 10 h / 5 °C View Scheme

1: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min 2: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature 3: 1) K2CO3, 2) 15percent HCl/dioxane / 1) H2O, 2) rt, overnight View Scheme

triethylamine in N,N-dimethyl-formamide Ambient temperature;

triethylamine in ethanol; water 16 h; Ambient temperature;