hydrogen; palladium on activated charcoal in methanol P=735.5 Torr; 2 h; Ambient temperature;

palladium

hydrogen; palladium in methanol P=760 Torr; 2 h; Ambient temperature;

1: 28percent aq. NH3 / 168 h / Ambient temperature 3: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7 4: benzene / 6 h / Heating 5: 40.8 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature 6: ethyl acetate; diisopropyl ether 7: 94 percent / 15percent HCl/dioxane / Ambient temperature 8: DCC / tetrahydrofuran / Ambient temperature 9: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min 10: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature 11: H2 / Pd / methanol / 2 h / 760 Torr / Ambient temperature View Scheme

2: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7 3: benzene / 6 h / Heating 4: 40.8 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature 5: ethyl acetate; diisopropyl ether 6: 94 percent / 15percent HCl/dioxane / Ambient temperature 7: DCC / tetrahydrofuran / Ambient temperature 8: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min 9: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature 10: H2 / Pd / methanol / 2 h / 760 Torr / Ambient temperature View Scheme

1: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7 2: benzene / 6 h / Heating 3: 40.8 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature 4: ethyl acetate; diisopropyl ether 5: 94 percent / 15percent HCl/dioxane / Ambient temperature 6: DCC / tetrahydrofuran / Ambient temperature 7: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min 8: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature 9: H2 / Pd / methanol / 2 h / 760 Torr / Ambient temperature View Scheme

1: benzene / 6 h / Heating 2: 40.8 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature 3: ethyl acetate; diisopropyl ether 4: 94 percent / 15percent HCl/dioxane / Ambient temperature 5: DCC / tetrahydrofuran / Ambient temperature 6: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min 7: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature 8: H2 / Pd / methanol / 2 h / 760 Torr / Ambient temperature View Scheme

1: DCC / tetrahydrofuran / Ambient temperature 2: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min 3: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature 4: H2 / Pd / methanol / 2 h / 760 Torr / Ambient temperature View Scheme

1: ethyl acetate; diisopropyl ether 2: 94 percent / 15percent HCl/dioxane / Ambient temperature 3: DCC / tetrahydrofuran / Ambient temperature 4: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min 5: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature 6: H2 / Pd / methanol / 2 h / 760 Torr / Ambient temperature View Scheme

1: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min 2: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature 3: H2 / Pd / methanol / 2 h / 760 Torr / Ambient temperature View Scheme