1: 1-chloro-4-iodobenzene With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=-20°C; 1 h; Inert atmosphere; 2: With lithium chlorozincate in tetrahydrofuran Inert atmosphere; 3: 1-(3-bromophenyl)ethanone With bis(dibenzylideneacetone)-palladium(0); dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in tetrahydrofuran T=25°C; Negishi cross-coupling reaction; 0.0833333 h; Inert atmosphere;