4-甲烷磺酰基-联苯-3-羧酸合成路线 （共 3 条）
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=90°C; Suzuki cross-coupling; 16 h;
参考文献
Faucher, Anne-Marie; White, Peter W.; Brochu, Christian; Grand-Maitre, Chantal; Rancourt, Jean; Fazal, Gulrez
Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 18 - 21
反应条件
1: 96 percent / Oxone / methanol; H2O / 16 h / 0 - 20 °C
2: 47 percent / K3PO4; Pd(PPh3)4 / dimethylformamide / 16 h / 90 °C
View Scheme
参考文献
Faucher, Anne-Marie; White, Peter W.; Brochu, Christian; Grand-Maitre, Chantal; Rancourt, Jean; Fazal, Gulrez
Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 18 - 21
反应条件
1.1: NaH / tetrahydrofuran / 0.08 h / 0 °C
1.2: 3.4 g / tetrahydrofuran / 0.25 h / 20 °C
2.1: 96 percent / Oxone / methanol; H2O / 16 h / 0 - 20 °C
3.1: 47 percent / K3PO4; Pd(PPh3)4 / dimethylformamide / 16 h / 90 °C
View Scheme
参考文献
Faucher, Anne-Marie; White, Peter W.; Brochu, Christian; Grand-Maitre, Chantal; Rancourt, Jean; Fazal, Gulrez
Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 18 - 21
