1: With caesium carbonate; palladium diacetate in water; N,N-dimethyl-formamide T=40°C; 4 h; 2: With hydrogenchloride; water in ethylene glycol dimethyl ether pH=3;

potassium carbonate; Ps-PPh3-Pd resin in tetrahydrofuran; ethanol; water T=80°C; 24 h; Product distribution / selectivity;