7-苄基-3-硫杂-7-氮杂双环[3.3.1]壬烷-9-酮合成路线 （共 8 条）
反应条件
1: 53 percent / benzene / 48 h / Heating 2: 84 percent / KOH; hydrazine / triethylene glycol / 6 h / 200 °C View Scheme
参考文献
Tyagi, Sameer; Couch, Kevin M.; Garrison, Gregory L.; Berlin, K. Darrell; Scherlag, Benajmin J.; Patterson, Eugene; Lazzara, Ralph
Organic Preparations and Procedures International, 1999 , vol. 31, # 4 p. 413 - 421
反应条件
sodium hydroxide; paraformaldehyde in methanol; diethyl ether; water; Petroleum ether
参考文献
Oklahoma State University
Patent: US4581361 A1, 1986 ;
反应条件
hydrogenchloride in water; acetic acid; paraformaldehyde
参考文献
Board of Regents of Oklahoma State University
Patent: US5084572 A1, 1992 ;
Title/Abstract Full Text Show Details
Board of Regents of Oklahoma State University
Patent: US5110933 A1, 1992 ;
反应条件
acetic acid in methanol
5 h; Heating;
参考文献
Bailey, Bruce R.; Berlin, K. Darrell; Holt, Elizabeth M.
Phosphorus and Sulfur and the Related Elements, 1984 , vol. 20, p. 131 - 138
反应条件
acetic acid in methanol
Heating;
参考文献
Smith, Gary S.; Berlin, K. Darrell; Zisman, Stan A.; Holt, Elizabeth M.; Green, Vicki A.; Helm, Dick Van Der
Phosphorus and Sulfur and the Related Elements, 1988 , vol. 39, p. 91 - 112
反应条件
acetic acid in methanol
dropwise addition of the ketone; reflux, 3.5 h; r.t., 48 h;
参考文献
Smith, Gary S.; Berlin, K. Darrell; Zisman, Stan A.; Holt, Elizabeth M.; Green, Vicki A.; Helm, Dick Van Der
Phosphorus and Sulfur and the Related Elements, 1988 , vol. 39, p. 91 - 112
反应条件
potassium hydroxide; hydrazine hydrate; 1,2-bis-(2-hydroxyethoxy)-ethane
T=145 - 150°C; 4 h;
参考文献
Bailey III; Berlin; Holt; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 758 - 767
反应条件
in diethyl ether
1 h; Ambient temperature;
参考文献
Bailey III; Berlin; Holt; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 758 - 767
