4-甲基-2-(4-吡啶)-5-噻唑羧酸乙酯合成路线 （共 3 条）
反应条件
1: With sodium hydroxide in tetrahydrofuran; etanol T=20°C; 1 h; 2: With hydrogenchloride in tetrahydrofuran; ethanol; water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6359134 B1, 2002 ;
Location in patent: Referential example 21 ;
US 6359134 B1
反应条件
in ethanol
3 h; Reflux;
参考文献
Reichelt, Andreas; Bailis, Julie M.; Bartberger, Michael D.; Yao, Guomin; Shu, Hong; Kaller, Matthew R.; Allen, John G.; Weidner, Margaret F.; Keegan, Kathleen S.; Dao, Jennifer H.
European Journal of Medicinal Chemistry, 2014 , vol. 80, p. 364 - 382
反应条件
in ethanol; ethyl acetate
参考文献
AJINOMOTO CO., INC
Patent: US2001/56123 A1, 2001 ;
US 20010056123 A1
