2,3-二氟-5-(三氟甲基)吡啶合成路线 （共 9 条）
反应条件
potassium carbonate; cesium fluoride in 1-methyl-pyrrolidin-2-one T=110 - 120°C; P=18.7519 - 22.5023 Torr; 15 - 24 h; Product distribution / selectivity;
参考文献
Pfleger, Christophe; Waldmeier, Pius; Wang, Shaoning
Patent: US2008/221327 A1, 2008 ;
Location in patent: Page/Page column 6; 9 ;
反应条件
cesium fluoride in dimethyl sulfoxide
反应条件
caesium fluoride; potassium fluoride in sulfolane
反应条件
cesium fluoride in dimethyl sulfoxide
反应条件
potassium carbonate; cesium fluoride in 1-methyl-pyrrolidin-2-one T=120°C; 16 h; Product distribution / selectivity;
参考文献
US2008/221327 A1, ;
Page/Page column 6 ;
反应条件
in tetrahydrofuran; methanol
反应条件
potassium carbonate in acetonitrile
2 h; Heating / reflux;
参考文献
Jolidon, Synese; Narquizian, Robert; Norcross, Roger David; Pinard, Emmanuel
Patent: US2006/149062 A1, 2006 ;
Location in patent: Page/Page column 7 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in N,N-dimethyl-formamide
T=125°C; 0.5 h; Microwave;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/76318 A2, 2007 ;
Location in patent: Page/Page column 62 ;
WO 2007/076318 A2
反应条件
NaH in dimethyl sulfoxide; paraffin
参考文献
The Dow Chemical Company
Patent: US4599105 A1, 1986 ;
