4-[2-(1-哌啶基)乙氧基]-苯甲酸合成路线 （共 6 条）
反应条件
thionyl chloride in tetrahydrofuran T=20 - 50°C;
参考文献
Sabatini, Stefano; Gosetto, Francesca; Manfroni, Giuseppe; Tabarrini, Oriana; Kaatz, Glenn W.; Patel, Diixa; Cecchetti, Violetta
Journal of Medicinal Chemistry, 2011 , vol. 54, # 16 p. 5722 - 5736
反应条件
1: With sodium hydroxide in methanol
T=20°C; 15 h;
2: With hydrogenchloride in methanol; water
参考文献
Sabatini, Stefano; Gosetto, Francesca; Manfroni, Giuseppe; Tabarrini, Oriana; Kaatz, Glenn W.; Patel, Diixa; Cecchetti, Violetta
Journal of Medicinal Chemistry, 2011 , vol. 54, # 16 p. 5722 - 5736
反应条件
sodium hydroxide in methanol
48 h;
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: K2CO3 / dimethylformamide / 1.5 h / 100 °C
2: 5 N aq. NaOH / methanol / 48 h
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: K2CO3 / dimethylformamide / 1.5 h / 100 °C
2: 5 N aq. NaOH / methanol / 48 h
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 100 °C
2: sodium hydroxide / methanol / 15 h / 20 °C
View Scheme
参考文献
Sabatini, Stefano; Gosetto, Francesca; Manfroni, Giuseppe; Tabarrini, Oriana; Kaatz, Glenn W.; Patel, Diixa; Cecchetti, Violetta
Journal of Medicinal Chemistry, 2011 , vol. 54, # 16 p. 5722 - 5736
