5-溴-n2-甲基吡啶-2,3-二胺合成路线 （共 4 条）
参考文献
MERZ PHARMA GMBH and CO. KGAA; HENRICH, Markus; WEIL, Tanja; HECHENBERGER, Mirko; MUeLLER, Sibylle; KAUSS, Valerjans; ZEMRIBO, Ronalds; ERDMANE, Elina; SMITS, Gints
Patent: WO2011/15343 A1, 2011 ;
Location in patent: Page/Page column 43 ;
WO 2011/015343 A1
参考文献
Grivas; Lindstrom
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 2 p. 467 - 471
反应条件
1: With iron; acetic acid in water
T=20°C; 0.666667 h;
2: With sodium hydroxide; water
参考文献
AMGEN INC.
Patent: WO2009/17822 A2, 2009 ;
Location in patent: Page/Page column 79; 80 ;
WO 2009/017822 A2
反应条件
1: water; tetrahydrofuran / 12 h / 20 °C
2: SnCl2·2H2O / ethyl acetate / 3.5 h / Reflux
View Scheme
参考文献
MERZ PHARMA GMBH and CO. KGAA; HENRICH, Markus; WEIL, Tanja; HECHENBERGER, Mirko; MUeLLER, Sibylle; KAUSS, Valerjans; ZEMRIBO, Ronalds; ERDMANE, Elina; SMITS, Gints
Patent: WO2011/15343 A1, 2011 ;
WO 2011/015343 A1
