2-[1-苄基-3-(1-甲基-1,2,3,6-四氢-4-吡啶基)-1H-吲哚-5-基]-N-甲基乙烷磺酰胺合成路线 （共 11 条）
反应条件
1.1: methanol / 25 - 30 °C
1.2: 4 h / 25 - 30 °C
2.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
2.2: 25 °C
3.1: potassium hydroxide; ethanol / 15 - 25 °C
4.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
5.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
View Scheme
参考文献
CIPLA LIMITED; RAO, Dharmaraj Ramachandra; KANKAN, Rajendra Narayanrao; CHIKHALIKAR, Sandip Vasant; GHAGARE, Maruti; CURTIS, Philip Anthony
Patent: WO2011/21000 A2, 2011 ;
