6-溴-4-甲基-2(1H)-喹啉酮合成路线 （共 10 条）
参考文献
Gazzetta Chimica Italiana, , vol. 66, p. 723,727
反应条件
2: H2SO4 View Scheme
参考文献
Journal of the Karnatak University, , vol. 1, p. 43,45
反应条件
1: H2SO4 View Scheme
参考文献
Journal of the Karnatak University, , vol. 1, p. 43,45
参考文献
Journal of the Karnatak University, , vol. 1, p. 43,45
反应条件
trichlorophosphate Heating;
参考文献
Davis, Steven E.; Rauckman, Barbara S.; Chan, Joseph H.; Roth, Barbara
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1936 - 1942
反应条件
in trichlorophosphate
参考文献
Burroughs Wellcome Co.
Patent: US4587341 A1, 1986 ;
反应条件
in trichlorophosphate
参考文献
THE WELLCOME FOUNDATION LIMITED
Patent: EP96214 B1, 1991 ;
反应条件
1: 6-bromo-4-methyl-quinolin-2-ol With sodium hydride in N,N-dimethyl-formamide 0.166667 h; 2: methyl iodide in N,N-dimethyl-formamide 1 h;
参考文献
Piala, Alexander; Mayi, Diyar; Handy, Scott T.
Tetrahedron, 2011 , vol. 67, # 23 p. 4147 - 4154
反应条件
1: 97 percent / POCl3 / Heating
2: 74 percent / ethanol / Heating
View Scheme
参考文献
Davis, Steven E.; Rauckman, Barbara S.; Chan, Joseph H.; Roth, Barbara
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1936 - 1942
反应条件
1: 97 percent / POCl3 / Heating
2: 74 percent / ethanol / Heating
3: 1) n-BuLi / 1) THF, hexane, -78 deg C, 5 min, 2) to -20 deg C
View Scheme
参考文献
Davis, Steven E.; Rauckman, Barbara S.; Chan, Joseph H.; Roth, Barbara
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1936 - 1942
