potassium carbonate in N,N-dimethyl-formamide 3 h; Heating;

1: conc.HCl / acetic acid / 1.42 h / Ambient temperature 2: pyridine / 2 h / 120 °C 3: KOH, pyridine / 4 h / 60 °C 4: 98 percent / sodium acetate / acetic acid / 4 h / 140 °C 5: 80 percent / H2 / 10percent Pd/C / ethyl acetate; methanol 6: AlBr3 / acetonitrile / 50 °C View Scheme

1: conc.HCl / acetic acid / 1.42 h / Ambient temperature 2: pyridine / 2 h / 120 °C 3: KOH, pyridine / 4 h / 60 °C 4: 97 percent / sodium acetate / acetic acid / 4 h / 140 °C 5: 91 percent / H2 / 10percent Pd/C / ethyl acetate; methanol 6: AlBr3 / acetonitrile / 50 °C View Scheme

1: conc.HCl / acetic acid / 1.42 h / Ambient temperature 2: pyridine / 2 h / 120 °C 3: KOH, pyridine / 4 h / 60 °C 4: 98 percent / sodium acetate / acetic acid / 4 h / 140 °C 5: 97 percent / H2 / 10percent Pd/C / ethyl acetate; methanol View Scheme

1: conc.HCl / acetic acid / 1.42 h / Ambient temperature 2: pyridine / 2 h / 120 °C 3: KOH, pyridine / 4 h / 60 °C 4: 86 percent / sodium acetate / acetic acid / 4 h / 140 °C 5: 92 percent / H2 / 10percent Pd/C / ethyl acetate; methanol 6: AlBr3 / acetonitrile / 50 °C View Scheme

1: conc.HCl / acetic acid / 1.42 h / Ambient temperature 2: pyridine / 2 h / 120 °C 3: KOH, pyridine / 4 h / 60 °C 4: 86 percent / sodium acetate / acetic acid / 4 h / 140 °C 5: 92 percent / H2 / 10percent Pd/C / ethyl acetate; methanol 6: AlBr3 / acetonitrile / 50 °C View Scheme

1: conc.HCl / acetic acid / 1.42 h / Ambient temperature 2: pyridine / 2 h / 120 °C 3: KOH, pyridine / 4 h / 60 °C 4: 98 percent / sodium acetate / acetic acid / 4 h / 140 °C 5: 97 percent / H2 / 10percent Pd/C / ethyl acetate; methanol 6: 98 percent / AlCl3 / acetonitrile / 10 h / 70 °C View Scheme

hydrogenchloride in acetic acid 1.41667 h; Ambient temperature; Yield given;