1: 91 percent / H2 / 10percent Pd/C / ethyl acetate; methanol 2: AlBr3 / acetonitrile / 50 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3595639', constants.ctx, '0')">sodium acetate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '506007', constants.ctx, '0')">acetic acid</a> <br />T=140&deg;C;&nbsp;4&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: K₂CO₃ / dimethylformamide / 3 h / Heating<br />2: conc.HCl / acetic acid / 1.42 h / Ambient temperature<br />3: pyridine / 2 h / 120 &deg;C<br />4: KOH, pyridine / 4 h / 60 &deg;C<br />5: 97 percent / sodium acetate / acetic acid / 4 h / 140 &deg;C<br /> <br /> &nbsp;