咪达普利拉苄酯,(羰基咪唑烷)叔-丁酯合成路线 （共 14 条）
反应条件
1: ethyl acetate; diisopropyl ether
2: 94 percent / 15percent HCl/dioxane / Ambient temperature
3: DCC / tetrahydrofuran / Ambient temperature
4: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min
View Scheme
参考文献
Hayashi, Kimiaki; Nunami, Ken-ichi; Kato, Jyoji; Yoneda, Naoto; Kubo, Masami; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 289 - 297
反应条件
1: 40.8 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature
2: ethyl acetate; diisopropyl ether
3: 94 percent / 15percent HCl/dioxane / Ambient temperature
4: DCC / tetrahydrofuran / Ambient temperature
5: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min
View Scheme
参考文献
Hayashi, Kimiaki; Nunami, Ken-ichi; Kato, Jyoji; Yoneda, Naoto; Kubo, Masami; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 289 - 297
反应条件
1: 94 percent / 15percent HCl/dioxane / Ambient temperature
2: DCC / tetrahydrofuran / Ambient temperature
3: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min
View Scheme
参考文献
Hayashi, Kimiaki; Nunami, Ken-ichi; Kato, Jyoji; Yoneda, Naoto; Kubo, Masami; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 289 - 297
反应条件
potassium tert-butylate
1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min; Multistep reaction;
参考文献
Hayashi, Kimiaki; Nunami, Ken-ichi; Kato, Jyoji; Yoneda, Naoto; Kubo, Masami; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 289 - 297
