反应条件
1: 2-bromo-4-fluorobenzonitrile With isopropylmagnesium chloride in tetrahydrofuran
T=-30°C; 3 h;
2: N,N-dimethyl-formamide in tetrahydrofuran
T=-30 - 20°C;
3: With hydrogenchloride in tetrahydrofuran; water
T=-10°C; 0.333333 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; CHEN, Zhidong; HAO, Ming-Hong; LIU, Weimin; LO, Ho-Yin; LOKE, Pui Leng; MAN, Chuk, Chui; MORWICK, Tina, Marie; NEMOTO, Peter, Allen; TAKAHASHI, Hidenori; TYE, Heather; WU, Lifen
Patent: WO2011/68821 A1, 2011 ;
Location in patent: Page/Page column 137 ;
WO 2011/068821 A1
