4-(4-氟苯基)-6-异丙基嘧啶-2-醇合成路线 (共 3 条)
反应条件
1: 3-methyl-butan-2-one; 4-fluorobenzoic acid ethyl ester With potassium tert-butylate in toluene
T=-9 - 10°C;
2: urea With hydrogenchloride in isopropyl alcohol; toluene
T=60 - 80°C; 160.5 h;
3: With sodium hydrogencarbonate in water
pH=7; Product distribution / selectivity;
参考文献
Butters, Michael; Lenger, Steven Robert; Murray, Paul Michael; Snape, Evan William
Patent: US2008/207903 A1, 2008 ;
Location in patent: Page/Page column 18 ;
反应条件
hydrogenchloride in ethanol; isopropyl alcohol
40 h; Heating / reflux; Product distribution / selectivity;
参考文献
Butters, Michael; Lenger, Steven Robert; Murray, Paul Michael; Snape, Evan William
Patent: US2008/207903 A1, 2008 ;
Location in patent: Page/Page column 17 ;
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide
T=-8.5 - 20°C; 4.16667 h;
参考文献
Butters, Michael; Lenger, Steven Robert; Murray, Paul Michael; Snape, Evan William
Patent: US2008/207903 A1, 2008 ;
Location in patent: Page/Page column 17 ;