2-(4-甲基四氢-2H-吡喃-4-基)乙酸合成路线 （共 5 条）
反应条件
trifluoroacetic acid in dichloromethane
T=20°C;
参考文献
GENENTECH, INC.
Patent: WO2006/69063 A1, 2006 ;
Location in patent: Page/Page column 107 ;
WO 2006/069063 A1
反应条件
water; sodium hydroxide in ethanol
T=0°C;
参考文献
GENENTECH,INC.; FORMA TM, LLC; YUEN, Po-Wai; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; DRAGOVICH, Peter; LIU, Xiongcai; PATEL, Snahel; ZAK, Mark; ZHAO, Guiling; ZHANG, Yamin; ZHENG, Xiaozhang
Patent: WO2013/127269 A1, 2013 ;
Location in patent: Page/Page column 181; 182 ;
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2010/272681 A1, 2010 ;
反应条件
1.1: copper(l) iodide / diethyl ether / 0.17 h / 0 °C / |Inert atmosphere
1.2: 2.5 h / -78 - 0 °C
2.1: water; sodium hydroxide / ethanol / 0 °C
View Scheme
参考文献
GENENTECH,INC.; FORMA TM, LLC; YUEN, Po-Wai; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; DRAGOVICH, Peter; LIU, Xiongcai; PATEL, Snahel; ZAK, Mark; ZHAO, Guiling; ZHANG, Yamin; ZHENG, Xiaozhang
Patent: WO2013/127269 A1, 2013 ;
反应条件
1.1: acetonitrile / 16 h / 70 °C
2.1: copper(l) iodide / diethyl ether / 0.17 h / 0 °C / |Inert atmosphere
2.2: 2.5 h / -78 - 0 °C
3.1: water; sodium hydroxide / ethanol / 0 °C
View Scheme
参考文献
GENENTECH,INC.; FORMA TM, LLC; YUEN, Po-Wai; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; DRAGOVICH, Peter; LIU, Xiongcai; PATEL, Snahel; ZAK, Mark; ZHAO, Guiling; ZHANG, Yamin; ZHENG, Xiaozhang
Patent: WO2013/127269 A1, 2013 ;
