4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-1-([2-(三甲基甲硅烷基)乙氧基]甲基)-1H-吡唑合成路线 （共 2 条）
反应条件
potassium carbonate in 1-methyl-pyrrolidin-2-one
T=20°C; 16 h; Inert atmosphere;
参考文献
SCHERING CORPORATION; TSUI, Hon-Chung; PALIWAL, Sunil; KIM, Hyunjin, M.; KEREKES, Angela, D.; CAPLEN, Mary Ann; ESPOSITE, Sara, J.; MCKITTRICK, Brian, A.; FISCHMANN, Thierry Olivier; DOLL, Ronald, J.; RAINKA, Matthew Paul; LI, Ang
Patent: WO2011/149874 A2, 2011 ;
Location in patent: Page/Page column 81-82 ;
反应条件
1: 2-(1H-Pyrazole-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane With sodium hydride in N,N-dimethyl-formamide
T=60°C; 0.333333 h;
2: trimethylsilyl ethoxymethyl chloride in N,N-dimethyl-formamide
T=60°C; 16 h;
参考文献
Alcon, Inc.
Patent: US2006/142307 A1, 2006 ;
Location in patent: Page/Page column 7 ;
US 20060142307 A1
