2-甲硫基-4-羟基-5-氰基嘧啶合成路线 （共 5 条）
反应条件
potassium carbonate in ethanol 48 h; Heating / reflux;
参考文献
Hutchison MediPharma Enterprises Limeted
Patent: US2008/255172 A1, 2008 ;
Location in patent: Page/Page column 70 ;
反应条件
1: S-methyl-isothiourea sulfate With potassium hydroxide in methanol T=0 - 20°C; 2: 2-cyano-3-ethoxy-acrylic acid ethyl ester in methanol T=0 - 20°C;
参考文献
US2009/270389 A1, ;
Page/Page column 43 ;
US 20090270389 A1
反应条件
potassium carbonate in ethanol; water T=85°C;
参考文献
European Journal of Medicinal Chemistry, , vol. 56, p. 30 - 38
反应条件
potassium hydroxide; sodium hydroxide in methanol; diethyl ether
参考文献
US2003/158218 A1, ;
US 20030158218 A1
参考文献
Warner-Lambert Company
Patent: US5620981 A1, 1997 ;
US 5620981 A
