4-氨基噻吩-2-甲酸甲酯合成路线 （共 9 条）
反应条件
hydrogenchloride; zinc in methanol Ambient temperature;
参考文献
Arcamone, Federico Maria; Animati, Fabio; Barbieri, Brunella; Configliacchi, Emanuela; D'Alessio, Roberto; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 774 - 778
反应条件
1: With sulfuric acid; nitric acid T=0 - 10°C; 2: With methanol; thionyl chloride T=20°C; Reflux; 3: With hydrogenchloride; iron; ammonium chloride in methanol; water T=20 - 70°C;
参考文献
US2010/68178 A1, ;
Page/Page column 16-17 ;
反应条件
1: thiophene-2-carboxylic acid With sulfuric acid; nitric acid T=0 - 10°C; 1.25 h; 2: methanol With thionyl chloride T=20°C; Reflux;
参考文献
WO2010/29577 A2, ;
Page/Page column 38-39 ;
反应条件
hydrogenchloride; zinc in ethanol
参考文献
Kiryanov, Andre A.; Seed, Alexander J.; Sampson, Paul
Tetrahedron Letters, 2001 , vol. 42, # 50 p. 8797 - 8800
反应条件
1: 95 percent / H2SO4 2: 60 percent / HNO3; H2SO4 3: 94 percent / Zn; HCl / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 50 p. 8797 - 8800
反应条件
1: 60 percent / HNO3; H2SO4 2: 94 percent / Zn; HCl / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 50 p. 8797 - 8800
反应条件
in diethyl ether 3 h; Ambient temperature;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 19, # 12 p. 1283 - 1286
Khimiya Geterotsiklicheskikh Soedinenii, , vol. 19, # 12 p. 1626 - 1629
反应条件
1.1: NaNO2; HCl; HPF6 1.2: 180 - 200 °C 2.1: 100 percent / Br2 / CHCl3 / 2.5 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 50 p. 8797 - 8800
反应条件
1: With hydrogenchloride; HPF6; sodium nitrite Balz-Schiemann reaction; 2: T=180 - 200°C;
参考文献
Kiryanov, Andre A.; Seed, Alexander J.; Sampson, Paul
Tetrahedron Letters, 2001 , vol. 42, # 50 p. 8797 - 8800
