4-甲基-5-氧代四氢-3-呋喃羧酸合成路线 （共 7 条）
反应条件
bei der Destillation;
参考文献
Fichter; Rudin
Chemische Berichte, 1904 , vol. 37, p. 1617
反应条件
hydrogen; palladium on activated charcoal in ethanol
2 h;
参考文献
Dowd; Shapiro; Kang
Tetrahedron, 1984 , vol. 40, # 16 p. 3069 - 3086
反应条件
1: 54 percent / 20percent HCl / 52 h / 38 °C
2: 70 percent / H2 / Pd/C / ethanol / 2 h
View Scheme
参考文献
Dowd; Shapiro; Kang
Tetrahedron, 1984 , vol. 40, # 16 p. 3069 - 3086
反应条件
1: LiAlH4, cc. HCl / benzene / 1.) ice-water bath, 30 min 2.) RT, 2.5 h 2.) 0 deg C, 5 min
2: 30.5 g / KHCO3 / 0.42 h / 65 °C
3: 54 percent / 20percent HCl / 52 h / 38 °C
4: 70 percent / H2 / Pd/C / ethanol / 2 h
View Scheme
参考文献
Dowd; Shapiro; Kang
Tetrahedron, 1984 , vol. 40, # 16 p. 3069 - 3086
反应条件
1: 30.5 g / KHCO3 / 0.42 h / 65 °C
2: 54 percent / 20percent HCl / 52 h / 38 °C
3: 70 percent / H2 / Pd/C / ethanol / 2 h
View Scheme
参考文献
Dowd; Shapiro; Kang
Tetrahedron, 1984 , vol. 40, # 16 p. 3069 - 3086
反应条件
1: benzene / 1.) 0 deg C 2.) room temp., 12 h
2: 1.) cobalt nitrate hexahydrate, NaBH4 / 1.) room temp., 20 min , water 2.) 30 min, acetone
View Scheme
参考文献
Dowd; Shapiro; Kang
Tetrahedron, 1984 , vol. 40, # 16 p. 3069 - 3086
反应条件
1: 90 percent / 30-33percent HBr in HOAc / dioxane / 1.) 0 deg C, 5 min 2.) room temp., 30 h
2: benzene / 1.) 0 deg C 2.) room temp., 12 h
3: 1.) cobalt nitrate hexahydrate, NaBH4 / 1.) room temp., 20 min , water 2.) 30 min, acetone
View Scheme
参考文献
Dowd; Shapiro; Kang
Tetrahedron, 1984 , vol. 40, # 16 p. 3069 - 3086
