1: 3-methoxy-4-hydroxybenzylamine hydrochloride With sodium hydroxide in water; N,N-dimethyl-formamide T=20°C; 1 h; Inert atmosphereCooling with ice; 2: n-heptanoic acid chloride in tetrahydrofuran; water; N,N-dimethyl-formamide T=20°C; 18 h; Inert atmosphereCooling with ice;

in diethyl ether; N,N-dimethyl-formamide Ambient temperature;

1: oxalyl chloride / 3 h 2: 59 percent / dimethylformamide; diethyl ether / Ambient temperature View Scheme

1,4-dioxane; sodium hydrogencarbonate