反应条件
1: 3-(5-morpholin-4-ylmethyl-1H-benzimidazol-2-yl)-1H-pyrazol-4-ylamine; 1,1'-carbonyldiimidazole in tetrahydrofuran 16 h; Reflux; 2: anhydrous cyclopropylamine in N,N-dimethyl-formamide T=100°C; 16 h;
参考文献
Howard, Steven; Berdini, Valerio; Boulstridge, John A.; Carr, Maria G.; Cross, David M.; Curry, Jayne; Devine, Lindsay A.; Early, Theresa R.; Fazal, Lynsey; Gill, Adrian L.; Heathcote, Michelle; Maman, Sarita; Matthews, Julia E.; McMenamin, Rachel L.; Navarro, Eva F.; O'Brien, Michael A.; O'Reilly, Marc; Rees, David C.; Reule, Matthias; Tisi, Dominic; Williams, Glyn; Vinkovic, Mladen; Wyatt, Paul G.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 2 p. 379 - 388